Researchers at Haukeland University Hospital in Bergen, Norway have combined a laboratory ultrasound technique called "sonoporation" with the commercially-available chemotherapy compound Gemcitabine.
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The aim was to increase the porosity of pancreatic cells with microbubbles and to help get the drug into cancer cells where it is needed.
This week at the Acoustical Society of America's 171st meeting, held May 23-27 in Salt Lake City, they are reporting some initial results, based on the outcomes of a phase I clinical trial involving 10 people undergoing treatment for pancreatic cancer.
They found the new approach nearly doubled the median survival time from 7 months to 18 months without increased chemotherapy dosage and with no added toxicity or additional side effects.
"When we compared the amount of treatment our patients were able to undergo, compared to a historical cohort, we saw a significant increase of treatment cycles," said Spiros Kotopoulis, a researcher at National Centre for Ultrasound in Gastroenterology at Haukeland University Hospital in Bergen and The Departments of Clinical Science & Medicine at the University of Bergen, where some of his collaborators are also based.
Before the technique is proven effective, approved for routine care and made widely available to patients with this type of cancer, it must undergo further testing in clinical trials involving more patients - something that may take years.
Nevertheless, these results are promising for a disease with an often poor prognosis. The one-year survival rate for all stages of pancreatic cancer combined is 20 percent, and the five-year survival rate is 6 percent, according to the American Cancer Society.
The concept of delivering payloads via ultrasound, sonoporation, has been around for decades, and was initially used to enhance gene uptake. Kotopoulis became involved while working on his doctorate at the University of Hull in the United Kingdom, ultimately delving into interactions between cells and bubbles during short bursts of ultrasound exposure.
During that time, a collaboration with a group of French biologists led to the technical development of forcing single microbubbles into a cell with ultrasound - opening the door to forcing any number of other compounds into the cell.
As one of the largest barriers to a drug's efficacy is its ability to permeate a cell membrane, this was a significant development - one Kotopoulis took with him to a postdoctoral fellowship in Bergen, translating the laboratory concepts to a clinical bedside.
For their phase I clinical trial, Kotopoulis and his colleagues recruited a cohort of 10 volunteers who had locally advanced or metastatic pancreatic adenocarcinoma.
To facilitate more rapid clinical translation, the researchers and clinicians agreed to use technology and materials already available on the market at every step.
"If this worked, in 20 years, we didn't want a hospital to have to purchase specialized, expensive, one-use equipment," he said. ■