POST Online Media Lite Edition



 

'Breakthrough' Alzheimer's cure has serious side effects

Christian Fernsby |
Scientists have questioned a “breakthrough” Alzheimer’s drug after more details of its side effects have been released.

Article continues below




Final clinical trial results for lecanemab show that the drug was able to slow the rate of decline in people’s memory and thinking as well as function over 18 months, and also helped people with day-to-day activities.

Dementia experts hailed a potential “historic moment” when some of the final results were published in September, but questions remained over lecanemab’s side effects.

The full results, published at the Clinical Trials on Alzheimer’s Disease conference in San Francisco confirm a “robust effect” of slowing of cognitive decline of 27 per cent compared to those people in the study who were not given the drug.

The trial, known as Clarity AD included 1,795 people with early-stage Alzheimer’s and mild cognitive impairment (MCI) due to Alzheimer’s, who received a bi-weekly infusion of either lecanemab or a placebo.

The paper, published in the New England Journal of Medicine, gave more details of a prominent side effect of lecanemab known as amyloid-related imaging abnormality (Aria), which involves a bleed or build up of fluid in the brain. It can vary from mild and negligible to quite severe.

Some 12.6 per cent (or 1 in 8) of those who received lecanemab developed Aria, while 1.7 per cent (less than 1 in 50) developed it in the placebo group. Although there were a similar number of deaths in both groups eight in the lecanemab group and seven in the placebo group scientists said further follow up is needed to understand whether Aria in certain patients is life threatening.

If so, it may be that patients receiving such treatments need to be excluded. Further studies will be able to identify the patients at risk and those patients who will maximally profit from the treatment.

The paper also suggests further studies to evaluate how effective and safe lecanemab is are ongoing, as a key question is whether clinical benefits are progressive in that they continue beyond the 18 months, and whether they are sustained.

Rob Howard, professor of old age psychiatry at UCL, asked whether the drug was safe. He said: “Recent reports of two deaths from strokes, attributed to a side-effect of the drug, are concerning. The data indicates that six lecanemab-treated patients suffered strokes during the trial compared with two in the placebo group. Treatment therefore does carry risks, and in some rare cases this can be severe or life-threatening.

“I suspect that the lack of demonstrable clinical effectiveness will mean that lecanemab will not be taken up widely within healthcare systems around the world, although there will always be those whose heart rules their head. We need to keep looking for better and safer dementia treatments and today’s results show that we are now on a believable path to doing so.”


CMA CGM launches call for projects worth €200m to step up pace of decarbonization of French shipping

 
The CMA CGM Group has launched a call for projects targeted at startups and businesses working on concrete solutions to step up the pace of decarbonization within all areas of the French shipping industry.
 
 

Latest

Switzerland: 140 million COVID masks set to expire this year
U.S. personal income rises in December 2022, spending falls
Spanish police seize 4.5 tons of cocaine from livestock carrier
Philips Q4 sales EUR 5.4 billion, 4,000 jobs cuts underway

NEWS

Coal train derails in Australia's Queensland state, no injuries

6.1 magnitude earthquake hits northwest China
U.S.: Frigid temperatures for parts of center and west
First international passenger flight takes off from Auckland Airport following deluge
Farmers hold Rail Roko protest in Punjab
Pakistan's anti narcotics force recovers 51 kg drugs, arrests 9
 

BUSINESS

Greece approves construction of floating gas and regasification unit off Athens

Highlights: January 23, 2023 - January 27, 2023
Logistics UK reacts to speculation about part-cancellation of HS2 Project
TABC President: Tunisia can be platform for exporting energy to Europe
Germany faces biggest teacher shortage in 50 years, association says
Electricity from renewable sources on the rise in EU
 

Trending Now

MOL first Japanese company to join First Movers Coalition's shipping sector

Use of neonicotinoids for seeds: France accelerating deployment of alternatives, will support sugar beet sector

Anglo American loads first LNG dual-fuelled vessel in chartered fleet

Ryanair Q3 profit €211m


POLITICS

Argentina, Germany agree to close EU-Mercosur free trade pact ‘soon’

Iran to join Shanghai Cooperation Organization
Iran and Kazakhstan eye increasing annual bilateral trade to $3 billion
Italian Prime Minister in Libya to conclude $8 billion gas deal
EU extends economic sanctions against Russia by six months
Iraq, France agree on energy, security cooperation
 

Today We Recommend

EU launches €100 million Regional Teachers' Initiative for Africa


Highlights 

New York: Zinc8 to relocate, invest $68 million, employ 500

Milo's Tea Company to create 103 new jobs in Spartanburg County, South Carolina

SK Battery America to open U.S. IT center, create 200 high-tech jobs in Roswell, Georgia


COMPANIES

Kern Liebers announces $10 million expansion in Mexico

Alcoa wind projects in Spain get approval
New York: Zinc8 to relocate, invest $68 million, employ 500
FedEx and Penstone inaugurate new plants in Guanajuato, Mexico
MOL first Japanese company to join First Movers Coalition's shipping sector
Socatra to install rotor sails on tanker Alcyone
 

CAREERS

Chiesi appoints Giuseppe Accogli as new group CEO

Foresters Financial Canada president Henry Auyeung to retire
Dollar Bank names Peter Kubiska new chief marketing officer
Bank of South Carolina CEO Fleetwood S. Hassell to retire
Drest appoints Henri Holm as CFO
VC4A introducing Vincent Hoogduijn as CEO
 

ECONOMY

Italy: Business confidence strengthens in January, consumer confidence weakens slightly

Sweden: Economic sentiment deteriorates further in January
U.S. trade deficit for goods soar 8.8% to $90.3b in December
Uzbekistan's economy grows 5.7 pct in 2022
Irish consumer confidence hit seven month high in January
Bank of Canada hikes rates
 

EARNINGS

Provident Bancorp Q4 income $2.7 million

PSB Holding income $4.39 million
Freedom Financial Holdings Q4 income $2,861,940
United Bancorporation of Alabama Q4 income $18.6 million
Pacific West Bancorp Q4 income $561 thousand
Ryanair Q3 profit €211m
 

OP-ED

Micromanaging is the worst enemy of efficiency and teamwork

Niger set to monetize massive gas reserves through Saharan natural gas pipeline
Putting the brakes on EV folly that choked the market
Oil discovery in Kavango Basin may mean huge benefits for Namibians
Cape Town and Dubai battle over Africa's energy future
Is America going to lose its superpower status?
 

AGRIFISH

Ireland: Minister McConalogue opens 2023 Nitrates Derogation applications

Finland confirms conditions and compensation levels of agricultural subsidies
Use of neonicotinoids for seeds: France accelerating deployment of alternatives, will support sugar beet sector
EU Court of Justice: No more derogations for use of bee-toxic neonicotinoids
New swine fever outbreak confirmed in Gauteng, South Africa
Eurostat releases food price monitoring tool
 

LEADERSHIP

Lucky CEO means bad luck for hiring company

Product images could boost food pantry use
The madness of fast service: I want it now!
How to build a resilient brand
Only 32% of employees believe their pay is fair
Corporate duty waivers limit organic company growth and innovation
 

CRIME

EAO issued third fine for Coastal GasLink project

Dutch central bank fines cryptocurrency exchange Coinbase 3.3 mln euros
Bloomberg to pay $5 million for misleading disclosures about its valuation methodologies for fixed income securities
Italy fines Yoox with over 5 million euro for misleading prices and limitations of right of withdrawal
Nexo agrees to pay $45 million in penalties and cease unregistered offering of crypto asset lending product
Virgin Atlantic fined for operating flights in prohibited airspace
 

Magazine

TRAVEL

IntercityHotel Berlin Airport BER opens

Art After School, the perfect way to spark imagination in your child
The world's biggest food fair in Berlin you don't wanna miss
Largest antiques show comes to small Texas town
Meet and see great artists from across the United States
Address Grand Creek Harbour opens its doors to guests
 

SEA, LAND, AIR

Honda Pilot TrailSport, fully equipped SUV with great ground clearance

2024 Corvette E-ray, electrified 4WD
Jaguar I-PACE is now more distinctive
2023 Toyota Prius expected this January
2023 Lincoln Corsair, advance features and ActiveGlide
Lamborghini Huracán Sterrato, first super sports car for any terrain
 

DESIGN

Curved sofas, elegant and gentle

Solios watches, from nature to luxury
Coats of faux fur, but not of faux style
Redifining kitchen space and experience with workstations
Dinning sofas, a soft addition to a modern dinning table
Patchwork carpets, vintage Persian carpets made with unparalleled skill
 

GADGETS

Harman Luxury Audio introduces new JBL Classic Series

KEF KC62, audio excellence and design ingenuity
Panasonic announces flagship OLED TV MZ2000
McIntosh MC451, 150 Watt vacuum tube and 300 Watt solid state amplifier
Headonia 2A3, luxury headphone amplifier that comes with gloves
ASUS launches ExpertBook B9 for executives
 

HEALTH

Indonesia to start rolling out COVID-19 vaccination for children under 6

Ipsen receives CHMP negative opinion for Palovarotene as treatment for fibrodysplasia ossificans progressiva in EU
Once-daily Sotyktu gets positive opinion as treatment for adults with moderate-to-severe plaque psoriasis
EMA update on shortages of antibiotics in EU
Researchers develop new urine test that can diagnose cancer
India launches 'world's first' intranasal COVID-19 vaccine
 

MEANTIME

NASA system predicts small asteroid to pass close by Earth this week

NASA, Pentagon developing nuclear-powered rocket for Mars
Milky Way found to be too big
Earth's inner core rotation paused
Airbus-built JUICE spacecraft set for lift-off to study Jupiter’s icy moons
Ripples in fabric of universe may reveal start of time