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Common pill halves risk of death in type of lung cancer

Christian Fernsby |
A pill has been shown to halve the risk of death from a certain type of lung cancer when taken daily after surgery to remove the tumor, according to clinical trial results presented on Sunday.

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The results were unveiled in Chicago at the largest annual conference of cancer specialists, hosted by the American Society for Clinical Oncology (ASCO).

Lung cancer is the form of the disease that causes the most deaths, with approximately 1.8 million fatalities every year worldwide.

The treatment developed by the pharmaceutical group AstraZeneca is called osimertinib and is marketed under the name Tagrisso. It targets a particular type of lung cancer in patients suffering from so-called non-small cell cancer, the most common type, and showing a particular type of mutation.

These mutations, on what is called the epidermal growth factor receptor, or EGFR, affect 10 percent to 25 percent of lung cancer patients in the United States and Europe, and 30 to 40 percent in Asia.

The clinical trial included some 680 participants at an early stage of the disease (stages 1b to 3a), in more than 20 countries. They had to have been operated on first to remove the tumor, then half of the patients took the treatment daily, and the other a placebo.

The result showed that taking the tablet resulted in a 51 percent reduction in the risk of death for treated patients, compared to placebo.

After five years, 88 percent of patients who took the treatment were still alive, compared to 78 percent of patients who took the placebo.

These data are "impressive," said Roy Herbst of Yale University, who presented them in Chicago. The drug helps "prevent the cancer from spreading to the brain, to the liver, to the bones," he added at a press conference.

About a third of cases of non-small cell cancers can be operated on when detected, he said.

"It is hard for me to convey, I think, how important this finding is," said Nathan Pennell of the Cleveland Clinic Foundation at the press conference.

"We started entering the personalized therapy era for early stage patients," said Pennell, who did not take part in the trials, and noted that "we should firmly close the door on one-size-fits-all treatment for people with non- small cell lung cancer."

Osimertinib is already authorized in dozens of countries for various indications, and has already been given to some 700,000 people, according to a press release from AstraZeneca.


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