First direct evidence that A. aegypti transmits Zika virus
Staff Writer |
In collaboration with colleagues from Mexico, University of Texas Medical Branch at Galveston researchers were the first to directly connect the Aedes aegypti mosquito with Zika transmission.
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In early 2015 the first Zika infections were described in Brazil, harbingers of an explosive hemispheric epidemic.
As of July 2016, local Zika infections have been reported in 39 countries and territories in the Americas, with the epidemic spreading throughout most of northern South America and nearly all of Central America and the Caribbean. Many countries in North America and Europe have also reported hundreds of imported cases.
"Because several experimental studies have suggested that A. aegypti is not highly susceptible to Zika virus infection and there has been a lack of direct evidence of A. aegypti infection during outbreaks, some scientists have speculated that other common tropical urban mosquitoes such as Culex quinquefasciatus could be involved," said UTMB professor Scott Weaver, senior author of this paper.
"We sought to more directly investigate which mosquito is responsible for spreading Zika virus so that we can selectively tailor our mosquito control efforts to a specific mosquito species' habits."
The signs and symptoms of Zika infection are similar to the mosquito-borne diseases chikungunya and dengue.
However, near the beginning of the outbreak in November of 2015 physicians in communities on the Mexico-Guatemala border reported to the Centro Regional de Investigacion Salud Publica an increase in the number of patents showing signs and symptoms thought to be different from those of chikungunya or dengue.
To investigate this outbreak further, during November and December last year, researchers from the Mexican National Institute of Public Health completed a house-to-house survey to identify patients who met the World Health Organization case definition of Zika virus infection in several locations in the state of Chiapas.
The researchers collected 119 blood samples with permission from people suspected of Zika virus infection. Zika virus was confirmed in 21 percent of the blood samples using a PCR-based test. No pregnant females were studied.
The researchers also gathered adult mosquitoes in and around 69 homes of suspected Zika patients using backpack aspirators, and identified Zika virus in several samples of A. aegypti but not in other mosquito species. ■