POST Online Media Lite Edition



 

Ibuprofen and similar NSAIDS can be associated with hastened progression of osteoarthritis symptoms

Christian Fernsby |
New data presented at the Radiological Society of North America's annual meeting suggests long-term use of non-steroidal anti-inflammatory drugs (NSAIDS), such as naproxen or ibuprofen, can be associated with hastened progression of osteoarthritis symptoms.

Article continues below




The researchers are cautious to stress the link is still observational and more work needs to be done to understand how these drugs could be linked to worsening arthritis inflammation.

The new research, led by Johanna Luitjens from the University of California, San Francisco, focused on the association between long-term NSAID use and an arthritis symptom called synovitis.

The synovial membrane is the connective tissue that lines joints like our knees or wrists, and synovitis is when that membrane becomes irritated and inflamed.

“Synovitis mediates development and progression of osteoarthritis and may be a therapeutic target,” explained Luitjens.

“Therefore, the goal of our study was to analyze whether NSAID treatment influences the development or progression of synovitis and to investigate whether cartilage imaging biomarkers, which reflect changes in osteoarthritis, are impacted by NSAID treatment.”

The researchers recruited over 1,000 subjects with moderate to severe osteoarthritis of the knee. Around one-quarter of the cohort received sustained NSAID therapy for over a year, while the remaining participants were not treated with the common painkillers. Each participant completed a knee MRI at the beginning of the study, and again four years later.

Evaluating a variety of MRI biomarkers of synovitis the researchers saw no long-term benefits from NSAID use over the four-year study period.

In fact, markers of joint inflammation were unexpectedly worse in the NSAID group at the end of the study, compared to those not taking the anti-inflammatory drugs.

“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” said Luitjens.

“The use of NSAIDs for their anti-inflammatory function has been frequently propagated in patients with osteoarthritis in recent years and should be revisited, since a positive impact on joint inflammation could not be demonstrated.”

Luitjens is careful to avoid suggesting NSAIDs are directly contributing to the worsening of synovitis over time.

She says it is possible the anti-inflammatory effects of these drugs are not directly making the condition worse but instead, those taking these painkillers could simply be moving more and hastening the progression of their condition.

"...patients who have synovitis and are taking pain-relieving medications may be physically more active due to pain relief, which could potentially lead to worsening of synovitis, although we adjusted for physical activity in our model," added Luitjens.

Ultimately, the results of this preliminary study yet to peer-reviewed and published in a journal leave clinicians and arthritis patients in a tricky situation.

NSAIDS are common pain-relieving agents for osteoarthritis patients, so there is no indication patients should stop taking these drugs for acute pain relief.

However, according to Luitjens, the long-term use of NSAIDs as a way to reduce synovitis and slow the progression of osteoarthritis is in doubt after these findings.


What to read next

Ibuprofen and similar NSAIDS an be associated with hastened progression of osteoarthritis symptoms
Genetic study reveals possible new routes to treating osteoarthritis
NSAIDs improve survival for certain colorectal cancer patients

Mayor of London Sadiq Khan launches biggest ever vehicle scrappage scheme

 
The Mayor of London, Sadiq Khan, has launched the £110 million scrappage scheme to support Londoners on lower incomes, disabled Londoners, charities, sole traders and business with 10 or fewer employees to replace or retrofit their old, polluting vehicles.
 
 

Latest

Air India flight from Sharjah makes emergency landing at Cochin Airport, India
Vienna's request for funding for fence on Bulgarian-Turkish border rejected
Sweden extends COVID-19 entry restrictions on travellers from China
Independent review: M. bovis spread in Wakanui, New Zealand

NEWS

Switzerland: 140 million COVID masks set to expire this year

Spanish police seize 4.5 tons of cocaine from livestock carrier
Coal train derails in Australia's Queensland state, no injuries
6.1 magnitude earthquake hits northwest China
U.S.: Frigid temperatures for parts of center and west
First international passenger flight takes off from Auckland Airport following deluge
 

BUSINESS

Greece approves construction of floating gas and regasification unit off Athens

Highlights: January 23, 2023 - January 27, 2023
Logistics UK reacts to speculation about part-cancellation of HS2 Project
TABC President: Tunisia can be platform for exporting energy to Europe
Germany faces biggest teacher shortage in 50 years, association says
Electricity from renewable sources on the rise in EU
 

Trending Now

MOL first Japanese company to join First Movers Coalition's shipping sector

Use of neonicotinoids for seeds: France accelerating deployment of alternatives, will support sugar beet sector

Anglo American loads first LNG dual-fuelled vessel in chartered fleet

Ryanair Q3 profit €211m


POLITICS

Argentina, Germany agree to close EU-Mercosur free trade pact ‘soon’

Iran to join Shanghai Cooperation Organization
Iran and Kazakhstan eye increasing annual bilateral trade to $3 billion
Italian Prime Minister in Libya to conclude $8 billion gas deal
EU extends economic sanctions against Russia by six months
Iraq, France agree on energy, security cooperation
 

Today We Recommend

EU launches €100 million Regional Teachers' Initiative for Africa


Highlights 

Mayor of London Sadiq Khan launches biggest ever vehicle scrappage scheme

New York: Zinc8 to relocate, invest $68 million, employ 500

Milo's Tea Company to create 103 new jobs in Spartanburg County, South Carolina


COMPANIES

CMA CGM launches call for projects worth €200m to step up pace of decarbonization of French shipping

Kern Liebers announces $10 million expansion in Mexico
Alcoa wind projects in Spain get approval
New York: Zinc8 to relocate, invest $68 million, employ 500
FedEx and Penstone inaugurate new plants in Guanajuato, Mexico
MOL first Japanese company to join First Movers Coalition's shipping sector
 

CAREERS

Chiesi appoints Giuseppe Accogli as new group CEO

Foresters Financial Canada president Henry Auyeung to retire
Dollar Bank names Peter Kubiska new chief marketing officer
Bank of South Carolina CEO Fleetwood S. Hassell to retire
Drest appoints Henri Holm as CFO
VC4A introducing Vincent Hoogduijn as CEO
 

ECONOMY

U.S. personal income rises in December 2022, spending falls

Italy: Business confidence strengthens in January, consumer confidence weakens slightly
Sweden: Economic sentiment deteriorates further in January
U.S. trade deficit for goods soar 8.8% to $90.3b in December
Uzbekistan's economy grows 5.7 pct in 2022
Irish consumer confidence hit seven month high in January
 

EARNINGS

Philips Q4 sales EUR 5.4 billion, 4,000 jobs cuts underway

Provident Bancorp Q4 income $2.7 million
PSB Holding income $4.39 million
Freedom Financial Holdings Q4 income $2,861,940
United Bancorporation of Alabama Q4 income $18.6 million
Pacific West Bancorp Q4 income $561 thousand
 

OP-ED

Micromanaging is the worst enemy of efficiency and teamwork

Niger set to monetize massive gas reserves through Saharan natural gas pipeline
Putting the brakes on EV folly that choked the market
Oil discovery in Kavango Basin may mean huge benefits for Namibians
Cape Town and Dubai battle over Africa's energy future
Is America going to lose its superpower status?
 

AGRIFISH

Ireland: Minister McConalogue opens 2023 Nitrates Derogation applications

Finland confirms conditions and compensation levels of agricultural subsidies
Use of neonicotinoids for seeds: France accelerating deployment of alternatives, will support sugar beet sector
EU Court of Justice: No more derogations for use of bee-toxic neonicotinoids
New swine fever outbreak confirmed in Gauteng, South Africa
Eurostat releases food price monitoring tool
 

LEADERSHIP

Lucky CEO means bad luck for hiring company

Product images could boost food pantry use
The madness of fast service: I want it now!
How to build a resilient brand
Only 32% of employees believe their pay is fair
Corporate duty waivers limit organic company growth and innovation
 

CRIME

EAO issued third fine for Coastal GasLink project

Dutch central bank fines cryptocurrency exchange Coinbase 3.3 mln euros
Bloomberg to pay $5 million for misleading disclosures about its valuation methodologies for fixed income securities
Italy fines Yoox with over 5 million euro for misleading prices and limitations of right of withdrawal
Nexo agrees to pay $45 million in penalties and cease unregistered offering of crypto asset lending product
Virgin Atlantic fined for operating flights in prohibited airspace
 

Magazine

TRAVEL

Tru by Hilton Monterrey Fundidora hotel opens in Mexico

IntercityHotel Berlin Airport BER opens
Art After School, the perfect way to spark imagination in your child
The world's biggest food fair in Berlin you don't wanna miss
Largest antiques show comes to small Texas town
Meet and see great artists from across the United States
 

SEA, LAND, AIR

Honda Pilot TrailSport, fully equipped SUV with great ground clearance

2024 Corvette E-ray, electrified 4WD
Jaguar I-PACE is now more distinctive
2023 Toyota Prius expected this January
2023 Lincoln Corsair, advance features and ActiveGlide
Lamborghini Huracán Sterrato, first super sports car for any terrain
 

DESIGN

Curved sofas, elegant and gentle

Solios watches, from nature to luxury
Coats of faux fur, but not of faux style
Redifining kitchen space and experience with workstations
Dinning sofas, a soft addition to a modern dinning table
Patchwork carpets, vintage Persian carpets made with unparalleled skill
 

GADGETS

Harman Luxury Audio introduces new JBL Classic Series

KEF KC62, audio excellence and design ingenuity
Panasonic announces flagship OLED TV MZ2000
McIntosh MC451, 150 Watt vacuum tube and 300 Watt solid state amplifier
Headonia 2A3, luxury headphone amplifier that comes with gloves
ASUS launches ExpertBook B9 for executives
 

HEALTH

Indonesia to start rolling out COVID-19 vaccination for children under 6

Ipsen receives CHMP negative opinion for Palovarotene as treatment for fibrodysplasia ossificans progressiva in EU
Once-daily Sotyktu gets positive opinion as treatment for adults with moderate-to-severe plaque psoriasis
EMA update on shortages of antibiotics in EU
Researchers develop new urine test that can diagnose cancer
India launches 'world's first' intranasal COVID-19 vaccine
 

MEANTIME

NASA system predicts small asteroid to pass close by Earth this week

NASA, Pentagon developing nuclear-powered rocket for Mars
Milky Way found to be too big
Earth's inner core rotation paused
Airbus-built JUICE spacecraft set for lift-off to study Jupiter’s icy moons
Ripples in fabric of universe may reveal start of time