POST Online Media Lite Edition



 

World-first COVID-19 alternating dose vaccine study launches in UK

Christian Fernsby |
Patients taking part in a new clinical study will soon receive different COVID-19 vaccines for their first or second dose.

Article continues below




Backed by £7 million of government funding, the study will be the first in the world to determine the effects of using different vaccines for the first and second dose – for example, using Oxford University/AstraZeneca’s vaccine for the first dose, followed by Pfizer/BioNTech’s vaccine for the second.

The study, run by the National Immunisation Schedule Evaluation Consortium (NISEC) across 8 National Institute for Health Research (NIHR) supported sites, will also gather immunological evidence on different intervals between the first and second dose for a mixed-vaccine regimen against control groups when the same vaccine is used for both doses.

A same-dose regimen is currently implemented for the national COVID-19 vaccination programme, and there are no current plans for this to change. Anyone who has received either the Pfizer or AstraZeneca vaccination as part of the UK-wide delivery plan will not be affected by this study.

They will receive their second dose from the same source and over the same 12-week interval.

The 13-month study will monitor the impact of the different dosing regimens on patients’ immune responses, which have the potential to be higher or lower than from the same dose regimen. Initial findings are expected to be released in the summer. The study has received ethics approval from the Research Ethics Committee, as well as approval from the Medicines and Healthcare products Regulatory Agency (MHRA).

Should the study show promising results, then the government may consider reviewing the vaccine regimen approach if needed, but only if proven to be safe and recommended by the Joint Committee on Vaccination and Immunisation (JCVI).

The study will initially have 8 different arms testing 8 different combinations, but more products may be added. The 8 arms include:

• 2 doses of the Oxford/AstraZeneca vaccine at 28 days apart
• 2 doses of the Oxford/AstraZeneca vaccine at 12 weeks apart – as a control group
• 2 doses of the Pfizer/BioNTech vaccine at 28 days apart
• 2 doses of the Pfizer/BioNTech vaccine at 12 weeks apart – as a control group
• the Oxford/AstraZeneca vaccine for the first dose, followed by the Pfizer/BioNTech vaccine for the second, at 28 days apart
• the Oxford/AstraZeneca vaccine for the first dose, followed by the Pfizer/BioNTech vaccine for the second, at 12 weeks apart
• the Pfizer/BioNTech vaccine for the first dose, followed by the Oxford/AstraZeneca vaccine for the second, at 28 days apart
• the Pfizer/BioNTech vaccine for the first dose, followed by the Oxford/AstraZeneca vaccine for the second, at 12 weeks apart

Over 800 patients are expected to take part in the study, referred to as the COVID-19 Heterologous Prime Boost study or ‘Com-Cov’, across 8 different sites across England – including in London, Birmingham and Liverpool.

Patients will be recruited over the course of February via the NHS COVID-19 Vaccine Research Registry, with vaccinations expected to start towards the middle of the month and initial results to be made available over the summer period. The UK public can volunteer to be contacted about taking part in the study and further vaccine studies by joining the registry.

The study has been classified as an Urgent Public Health study by the NIHR and is being undertaken by NISEC and the Oxford Vaccine Group, with funding of £7 million from the government through the Vaccines Taskforce.

National Clinical Lead for the NIHR COVID Vaccine Research Programme, Professor Andrew Ustianowski, said: "This is another exciting step forward in finding a variety of vaccine options for the UK and globally, for which the NIHR is integral to ensuring the participant recruitment for this study and the gaining of robust data on safety and effectiveness.

"We need people from all backgrounds to take part in this trial, so that we can ensure we have vaccine options suitable for all. Signing up to volunteer for vaccine studies is quick and easy via the NHS Vaccine Research Registry."


What to read next

Slight brain zap during sleep could boost memory
Nigeria goes one year without a case of polio
WHO coordinates visit to China to investigate origin of coronavirus

New York Governor revealers list of all places when kids can get COVID vaccine

 
Governor Kathy Hochul announced the re-launch of #VaxtoSchool.
 
 

Latest

New York: Construction started on $33 million Three Mile Harbor housing development
50 beaches in England and Wales under sewage alerts
Train services disrupted, buildings evacuated after fire broke out near London Bridge
Sonic Automotive acquires Audi Owings Mills in Maryland

NEWS

Malaysia's passenger flight denied landing at Myanmar's Yangon Airport

American naval training aircraft crashes in Texas
Plane with damaged wing makes emergency landing in Irkutsk region
Louisiana: Vernon Parish man arrested for timber theft
U.S.: Excessive heat for south and west, flash flooding conditions in southwest
Iran seizes unprecedented amount of crystal meth
 

BUSINESS

Norway's July gas exports hit record high

Nearly 70% of America's top executives affiliated with Republicans
Russian gas supplies via Ukraine, Nord Stream to remain at previous volumes on Wednesday
EU economy greenhouse gases still below pre-COVID levels
Hundreds of workers at Liverpool port vote to strike over pay
Five more grain-carrying ships leave Ukrainian ports
 

Trending Now

Sonic Automotive acquires Audi Owings Mills in Maryland

New York Governor revealers list of all places when kids can get COVID vaccine

New York: Construction started on $33 million Three Mile Harbor housing development

50 beaches in England and Wales under sewage alerts


POLITICS

President Biden signs climate, health care package

Czech Republic seizes part of Gazprom’s gas storage capacity
Minister Ng to strengthen Canada-Philippines ties with upcoming visit
New trading scheme in UK cuts tariffs on hundreds of everyday products
Hungarian government to fast-track domestic gas production
Illinois Governor announces $34.6 billion investment in transportation over six years
 

Today We Recommend

Nearly 70% of America's top executives affiliated with Republicans


Highlights 

Mainstream Renewable Power pledges to create 100 new jobs in Ireland

Navitas Semiconductor acquires GeneSiC Semiconductor for $100 million

Shoprite acquires 100 new fuel-efficient Scania Euro V trucks


COMPANIES

Ponsse launches new technology: electric forest machine

Mainstream Renewable Power pledges to create 100 new jobs in Ireland
Next.e.GO Mobile starts building €720mn electronic car plant in North Macedonia
EIB to support Ryvu Therapeutics with €22 million
Gazprom does not rule out gas prices in Europe over $4,000 in winter
Joysbio developed two new monkeypox tests that deliver results in 15 minutes
 

CAREERS

Philips appoints Roy Jakobs as president and CEO

Daseke appoints Bruce Blaise to board
Island Pacific appoints Herman Chiu as CFO
Horizon Bancorp appoints Thomas M. Prame as president
Encora appoints Deepak Bhandari as EVP, head of corporate development
Firmenich: Maurizio Clementi interim president of taste and beyond division
 

ECONOMY

Russian Economy Ministry expects inflation to reach 13.4% in 2022, GDP to drop to 4.2%

Indonesia sets economic growth at 5.3 percent, inflation at 3.3 percent in 2023
Slovenia's Q2 GDP growth slows to 8.2 pct y-o-y
UK inflation hits 10.1% in 40-year high
U.S. housing market index drops to two-year low in August
German investor confidence falls
 

EARNINGS

Walmart Q2 profit advances

Home Depot Q2 profit climbs
BioMar achieves record Q2
AD Ports Group Q2 net profit surges 59%
Strauss Group H1 revenue increased 8%
BHP net profit nearly triples
 

OP-ED

Micromanaging is the worst enemy of efficiency and teamwork

Niger set to monetize massive gas reserves through Saharan natural gas pipeline
Putting the brakes on EV folly that choked the market
Oil discovery in Kavango Basin may mean huge benefits for Namibians
Cape Town and Dubai battle over Africa's energy future
Is America going to lose its superpower status?
 

AGRIFISH

First 100 Ukrainian farmers compensated through WFCU agricultural loan reimbursement program

Commission approves €218 million Bulgarian scheme to support agricultural producers
HPAI case in Pennsylvania affects Warren County in New Jersey
South Africa suspends cattle movement to control foot and mouth disease
Russia sent first batches of fodder meal from Kursk region to Vietnam
Rosselkhoznadzor: Illegal import of more than 500,000 doses of vaccine against low pathogenic avian infections stopped
 

LEADERSHIP

51% of supply chain leaders increased number of network locations

If company overcomes post-IPO innovation slump, it will survive longer
62% of consumers will stop buying from brands that compromise products to cut costs
Companies must invest to avoid supply chain scandal or pay the price in lost consumers
How awards, recognition decrease inventors' creativity
Keeping employees is harder than ever. And we don't have good news
 

CRIME

Massachusetts AG reaches settlement with opioid maker Endo

Google LLC to pay $60 million for collecting users' location data
Ex-company director from Solihull to pay £11,200 for exporting banned waste
South Korea fines 11 companies $197.5 million for price fixing
Healthcare workers in Italy put at risk due to aggravated fraud relating to protective face masks and suits
South Africa's Special Tribunal orders freeze of Transnet executives' assets
 

Magazine

TRAVEL

Radisson Resort Plaza Skiathos opens in Greece

Dublin Horse Show 2022, a packed programme of races, food and drink
Enjoy the best Greek food in Alaska
The SureStay Hotel by Best Western Rockford East opens in Rockford, Illinois
Avani Chaweng Samui Hotel & Beach Club opens in Thailand
Buffalo Bill is coming to Manitowoc with his Wild West show
 

SEA, LAND, AIR

New Ford Maverick Tremor Off-Road Package revealed

Porsche unveils newest generation of 911 GT3 R
2023 Subaru Crosstrek sells like hotcakes
New Mercedes‑Benz GLC, at home on any terrain
GMC unleashes new 2023 Sierra 1500 AT4X AEV Edition
First BMW M3 Touring presented
 

DESIGN

Clean and luxurious men's watches

Nobody's Child, everybody's favorite
Freddy WR.UP, pants that hug you in all the right places
Stylishly luxurious house design
Great design ideas that might not work for you
Garden mirrors, explore new views of your garden
 

GADGETS

Pro-Ject X8 turntable, superior noise suppression and great sound

Shure MV7 professional dynamic microphone now available in new limited-edition color
Forget streaming services, use McIntosh MR89 to enjoy AM/FM music
Infinix NOTE 12 PRO, first smartphone powered by MediaTek Helio G99
MW75 active noise-cancelling headphones, variety of new features
Parasound JC 1+ mono power amplifier by John Curl, pure delight
 

HEALTH

FDA to allow sale of hearing aids over the counter

West Nile virus kills 1 in Serbia
Infected blood victims in UK to receive £100,000 interim compensation payment
Malta receives first shipment of monkeypox vaccine
Iran reports first monkeypox case
Uruguay decreed universal and free care for hyperacute stroke treatment
 

MEANTIME

Black hole ready for its close-up

Earth's water may be from asteroids
Climate change increasing risk of megaflood in California, Americans ill-prepared and uninsured
Brightest stars in the night sky can strip Neptune-sized planets to their rocky cores
California weather is trending toward extremes
Swiss mountain pass ice to melt completely within weeks