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Zika vaccine works in early human trial

Staff Writer |
An experimental vaccine for the Zika virus has shown signs of success in an early human trial.

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The vaccine safely produced Zika-specific antibodies in 100 percent of the people involved in the study.

"Zika virus continues to be a threat to people living in the Americas and the Caribbean," said study author Dr. Pablo Tebas, a professor of infectious diseases at the University of Pennsylvania in Philadelphia.

"With these new results, we are one step closer to hopefully finding a way to prevent infection, which can cause serious birth defects and developmental delays in babies born to women who are infected with Zika," he said.

The synthetic DNA-based Zika vaccine is known as GLS-5700. Unlike some vaccines that use weakened or killed versions of a virus, the experimental Zika vaccine contains synthetic DNA instructions that enable the immune system to neutralize the virus.

The vaccine was developed by Inovio Pharmaceuticals, GeneOne Life Science and The Wistar Institute.

"Synthetic DNA vaccines are an ideal approach for emerging infectious diseases like Zika," study co-author David Weiner said in a Wistar news release. He's director of the institute's Vaccine & Immunotherapy Center.

Weiner said this new generation of DNA vaccines has significant advantages. They can be designed and manufactured rapidly. They also appear to be highly predictable for the generation of immunity in humans.

Plus, these vaccines are more stable than most traditional vaccines, "making them exceptionally practical to distribute during outbreaks, especially in regions where resources are limited and we need to be able to respond quickly to curb an emerging epidemic," Weiner said.

The trial included 40 people. It was conducted in 2016 from August to September. The participants were divided into two groups that received two different doses of the vaccine when the study began.

The study volunteers received additional doses at four and 12 weeks. Each dosage was delivered with Cellectra, a device that produces small, electric currents that help the body produce an immune response to the vaccine.

Two weeks after receiving the final dose of the vaccine, all 40 of the people involved in the study developed Zika-specific antibodies, the study showed.

The researchers noted that 80 percent of the participants developed significant protection against the virus. None of the people had a negative reaction to the vaccine.


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